9/25/2023 0 Comments Wen jing li![]() However, the role of the NGAL-megalin complex has not been well described. ![]() NGAL participates in controlling iron homeostasis, the activation of pro-inflammatory and pro-fibrosis signaling pathways through 24p3R. NGAL has two receptors, the 24p3R, and the megalin receptor. NGAL interacted with MMP-9 to increase plaque vulnerability. The roles and mechanisms of NGAL in ischemic heart disease. Matrix metalloproteinase Myeloperoxidase Myocardial infarction Neutrophil degranulation Neutrophil elastase Neutrophil gelatinase-associated lipocalin Neutrophils. Myeloperoxidase (MPO) Neutrophil elastase (NE) Neutrophil gelatinase-associated lipocalin (NGAL) Matrix metalloproteinase 8 (MMP-8) Matrix metalloproteinase 9 (MMP-9). In this review, we reviewed the current research progress of neutrophil granules in MI and discusses neutrophil degranulation associated diagnosis and treatment strategies. MPO, NE, NGAL, MMP-8, MMP-9, cathelicidin, arginase and azurocidin) released from neutrophil degranulation show different effects through diverse mechanisms in MI. Both neutrophils infiltrating and neutrophil degranulation take part in the injury and repair process immediately after the onset of MI. Video abstract Neutrophils played a crucial role throughout the process of MI, and neutrophil degranulation was the crucial step for the regulative function of neutrophils. This article reviewed the current research progress of neutrophil granules in MI and discusses neutrophil degranulation associated diagnosis and treatment strategies. Especially, granule proteins released by neutrophil degranulation after neutrophil activation have been suggested to involve in the process of MI. Neutrophils have been increasingly recognized to exert important functions in MI. Recently, researchers reported that neutrophils are closely related to the severity and prognosis of patients with MI, and neutrophil to lymphocyte ratio in post-MI patients had predictive value for major adverse cardiac events. Numerous studies have confirmed that neutrophils play important roles in inflammation and innate immunity, which provide the first line of defense against microorganisms by producing inflammatory cytokines and chemokines, releasing reactive oxygen species, and degranulating components of neutrophil cytoplasmic granules to kill pathogens. Since MI could develop into a life-threatening emergency and could also seriously affect the life quality of patients, continuous efforts have been made to create an effective strategy to prevent the occurrence of MI and reduce MI-related mortality. infarction (MI) is one of the most common cardiac emergencies with high morbidity and is a leading cause of death worldwide. 9 Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, People's Republic of China. 8 Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, People's Republic of China. 7 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China. 6 Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, People's Republic of China. 5 Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, People's Republic of China. 4 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China. ![]() ![]() 1 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China. 3 Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, People's Republic of China.2 Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, People's Republic of China.1 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China.
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